Anti-Phospho-IRAK1(Thr387) Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-Phospho-IRAK1(Thr387) Polyclonal Antibody
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Mouse ; Human预测
交叉反应：： Dog;Pig;Cow;Rabbit
应用： ELISA ; FCM ; IF ; IHC ; WB
稀释比例： WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 0.2μg /Test. IF 1:100-500.

抗体信息

靶标： Phospho-IRAK1(Thr387)
别名： IRAK (phospho T387);p-IRAK (phospho T387);IRAK1 (Phospho-Thr387);IRAK1 (Phospho-T387);IRAK1 (p-Thr387);Il1rak;Il1rak;Interleukin 1 receptor associated kinase 1;Interleukin 1 receptor associated kinase 1
背景说明： Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation.
Swiss Prot： P51617
Gene ID： 3654
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human IRAK1 around the phosphorylation site of Thr387
理论分子量： 77kDa

其它标识

纯化方法： Affinity purification
储存液： 0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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