Anti-AF-6（B-5） Monoclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-AF-6（B-5） Monoclonal Antibody
中文名称： 丝状肌动蛋白结合蛋白抗体
规格： 1ml
宿主： Mouse
克隆类型： Monoclonal antibody
亚型： IgG2aK克隆号 B-5
交叉反应：： Human ; Rat ; Mouse
应用： WB ; ELISA ; IHC-P ; IF ; IP
稀释比例： WB 1:100-1000. IP 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate). IF 1:50-500. IHC 1:50-500. ELISA 1:30-3000.

抗体信息

靶标： ARRB1
别名： AF 6; AF6; AFAD_HUMAN; Afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT 4; MLLT4; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 4; Myeloid/lymphoid or mixed lineage leukemia translocated to 4; Protein AF 6; Protein Af-6; Protein AF6; RP3 431P23.3; 5033403D15Rik; Gm314; I-afadin; Mllt4; S-afadin.
背景说明： The dynamics of a cell-cell interface such as tight junctions or adherensjunctions are important in many developmental, physiological and pathological processes. AF-6 (MLLT4: myeloid/lymphoid or mixed-lineage leukemia translocated to 4) is a 1,612 amino acid protein that contains two N-terminal Ras binding domains (RBD) and a GLGF motif, and is implicated in Ras-mediated signaling events occurring at peripheral cell-cell junctions. AF-6 interacts with F-Actin and Profilin in cell-cell junctions, and may modulate Actin modeling near adhesion complexes. Furthermore, AF-6 coordinates junction adhesion molecule (JAM) recruitment to intercellular junctions through a PDZ domain. Developing mice deficient in AF-6 activity display a loss of neuroepithelial polarity, suggesting that AF-6 activity is an important regulator of cell-cell junctions that influence apical/basolateral asymmetry
Swiss Prot： P55196
Gene ID： 4301
亚细胞定位： Cell membrane
免疫原： Recombinant fusion protein of Human AF-6
理论分子量： 207kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with < 0.1% sodium azide and 0.1% gelatin.
储存条件： Store at -20℃. Avoid freeze / thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。