Anti-ULK3 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-ULK3 Polyclonal Antibody
中文名称： 丝氨酸/苏氨酸蛋白激酶ULK3抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human
应用： WB
稀释比例： WB 1:5000-8000.

抗体信息

靶标： ULK3
别名： DKFZP434C131, FLJ90566, Serine/threonine-protein kinase ULK3, ULK3_HUMAN, unc 51 like kinase 3 (C. elegans), Unc-51-like kinase 3
背景说明： Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Swiss Prot： Q6PHR2
Gene ID： 25989
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human ULK3
Public Immunogen Range： 250-300/472aa
理论分子量： 24/53kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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