Anti-PPIF Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PPIF Polyclonal Antibody
中文名称： 肽酰脯氨酰异构酶F抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB ; IF ; IHC
稀释比例： WB 1:2000-1:5000. IHC 1:50-200.IF 1:50-200.

抗体信息

靶标： PPIF
别名： CyP-D;CypD;CyP-M;Rotamase F
背景说明： PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Swiss Prot： P30405
Gene ID： 10105
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human PPIF
Public Immunogen Range： 110-160/207aa
理论分子量： 16/22kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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