Anti-PTTG1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PTTG1 Polyclonal Antibody
中文名称： 垂体肿瘤转化基因抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IHC
稀释比例： IHC 1:100-300.

抗体信息

靶标： PTTG1
别名： EAP1; HPTTG; PTTG; TUTR1; securin
背景说明： The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
Swiss Prot： O95997
Gene ID： 9232
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of human PTTG1
Public Immunogen Range： 35-85/202aa
理论分子量： 22kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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