Anti-COL4A3 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-COL4A3 Polyclonal Antibody
中文名称： 肿瘤抑素抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： WB ; IHC
稀释比例： WB 1:1000-1:3000. IHC 1:50-200.

抗体信息

靶标： COL4A3
别名： Collagen alpha-3(IV) chain, Alpha 3 type IV collagen, Alpha3 type IV collagen, COL4A 3, Collagen IV alpha 3 polypeptide, Collagen type IV alpha 3 (Goodpasture antigen), Collagen type IV alpha 3, Goodpasture antigen,
背景说明： Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Swiss Prot： Q01955
Gene ID： 1285
亚细胞定位： Cell membrane Cytoplasm
免疫原： A synthetic peptide of human COL4A3
Public Immunogen Range： 1420-1470/1670aa
理论分子量： 135/142/161kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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