Anti-TEAD2 Polyclonal Antibody,BR

英文名称:Anti-TEAD2 Polyclonal Antibody
宿主:Rabbit
别名:TEAD2;ETF;TEAD-2;TEF-4;TEF4;TEA domain transcription factor 2
交叉反应:Human
应用:IHC
稀释比例:IHC 1:100-300.
蛋白分子量:35/49kDa
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:Recombinant protein of human TEAD2
亚细胞定位:Nucleus Cytoplasm
Swiss Prot:Q15562
背景资料:Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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