Anti-METTL14 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-METTL14 Polyclonal Antibody
中文名称： N6-腺苷甲基转移酶非催化亚基抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： WB ; IHC
稀释比例： WB 1:2000-5000. IHC 1:25-100.

抗体信息

靶标： METTL14
别名： KIAA1627;METTL14;hMETTL14;methyltransferase like 14
背景说明： The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis . In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core . N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity).
Swiss Prot： Q9HCE5
Gene ID： 57721
亚细胞定位： Nucleus
免疫原： Recombinant protein of human METTL14
Public Immunogen Range： 159-456aa
理论分子量： 52kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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