Anti-PRKAG1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PRKAG1 Polyclonal Antibody
中文名称： 5‘-AMP激活蛋白激酶亚基γ-1抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:2000-5000. IHC 1:50-200.

抗体信息

靶标： PRKAG1
别名： 5 AMP activated protein kinase gamma 1 subunit,5 AMP activated protein kinase subunit gamma 1,5-AMP-activated protein kinase subunit gamma-1,AAKG1_HUMAN,AMP activated protein kinase noncatalytic gamma 1 subunit,AMPK gamma 1 chain,AMPK gamma1,AMPK subunit gamma-1,AMPKg,MGC8666,PRKAG 1,PRKAG1,Protein kinase AMP activated gamma 1 non catalytic subunit,protein kinase, AMP-activated, noncatalytic gamma-1
背景说明： AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Swiss Prot： P54619
Gene ID： 5571
亚细胞定位： Nucleus Cytoplasm Secreted
免疫原： A synthetic peptide of Human PRKAG1
Public Immunogen Range： 95-145/331aa
理论分子量： 34/38/39kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。