Anti-SEPTIN2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SEPTIN2 Polyclonal Antibody
中文名称： 神经前体细胞表达发育下调蛋白5抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC1:50-200.

抗体信息

靶标： SEPTIN2
别名： SEPT2;DIFF6;NEDD-5;NEDD5;Pnutl3;hNedd5;septin-2
背景说明： Filament-forming cytoskeletal GTPase. Forms a 4filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
Swiss Prot： Q15019
Gene ID： 4735
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human SEPTIN2
Public Immunogen Range： 1-271aa
理论分子量： 41/45kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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