Anti-CPSF4 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CPSF4 Polyclonal Antibody
中文名称： 切割和多腺嘌呤化特异性因子4抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:25-100.

抗体信息

靶标： CPSF4
别名： CPSF4;CPSF30;NAR;NEB-1;NEB1;cleavage and polyadenylation specific factor 4
背景说明： Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Swiss Prot： O95639
Gene ID： 10898
亚细胞定位： Nucleus Cytoplasm
免疫原： Recombinant protein of human CPSF4
Public Immunogen Range： 1-269aa
理论分子量： 27/30kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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