Anti-RFFL Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RFFL Polyclonal Antibody
中文名称： E3泛素-蛋白连接酶rififylin抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:25-100.

抗体信息

靶标： RFFL
别名： RFFL;CARP-2;CARP2;FRING;RIFIFYLIN;RNF189;RNF34L;E3 ubiquitin-protein ligase rififylin
背景说明： E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Swiss Prot： Q8WZ73
Gene ID： 117584
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human RFFL
Public Immunogen Range： 1-363aa
理论分子量： 37/40/41kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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