Anti-CSNK2A1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CSNK2A1 Polyclonal Antibody
中文名称： 丝/苏氨酸蛋白质激酶II α抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： CSNK2A1
别名： CK2A1;CKII;CSNK2A3;OCNDS;Cka1;Cka2;casein kinase 2 alpha 1
背景说明： Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes; such as cell cycle progression; apoptosis and transcription; as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis; functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis; phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8; and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I; II; III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B; STAT1; CREB1; IRF1; IRF2; ATF1; SRF; MAX; JUN; FOS; MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37; which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection; phosphorylates various proteins involved in the viral life cycles of EBV; HSV; HBV; HCV; HIV; CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry.
Swiss Prot： P68400
Gene ID： 1457
亚细胞定位： Nucleus
免疫原： A synthetic peptide of Human CSNK2A1
Public Immunogen Range： 210-260/391aa
理论分子量： 29/45kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。