Anti-WWTR1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-WWTR1 Polyclonal Antibody
中文名称： 包含WW结构域转录调节因子1抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC 1:50-200.

抗体信息

靶标： WWTR1
别名： Transcriptional co activator with PDZ binding motif, Transcriptional coactivator with PDZ binding motif, Transcriptional coactivator with PDZ-binding motif, WW domain containing transcription regulator 1, WW domain containing transcription regulator protein 1, WW domain-containing transcription regulator protein 1, WWTR 1, WWTR1, WWTR1_HUMAN
背景说明： Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Swiss Prot： Q9GZV5
Gene ID： 25937
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of Human WWTR1
Public Immunogen Range： 280-330/400aa
理论分子量： 44kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。