Anti-PRKAR2B Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PRKAR2B Polyclonal Antibody
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： PRKAR2B
别名： AI451071;AW061005;cAMP dependent protein kinase type II beta regulatory chain;cAMP dependent protein kinase type II beta regulatory subunit;cAMP-dependent protein kinase type II-beta regulatory subunit;H RG363E19.2;KAP3_HUMAN;MGC116401;Pkarb2;PRKAR 2;PRKAR2;PRKAR2B;Protein kinase cAMP dependent regulatory type II beta;RATDNA;RII beta;RII(beta);RIIbeta;WUGSC:H RG363E19.2;
背景说明： cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
Swiss Prot： P31323
Gene ID： 5577
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of Human PRKAR2B
Public Immunogen Range： 35-85/418aa
理论分子量： 46kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。