Anti-SMAD3 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SMAD3 Polyclonal Antibody
中文名称： 细胞信号转导分子SMAD3抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; WB
稀释比例： WB 1:2000-5000. IHC 1:25-100.

抗体信息

靶标： SMAD3
别名： HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MADH3;SMAD3
背景说明： Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Swiss Prot： P84022
Gene ID： 4088
亚细胞定位： Cytoplasm Cell membrane
免疫原： A synthetic peptide of Human SMAD3
Public Immunogen Range： 5-55/425aa
理论分子量： 26/36/43/48kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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