Anti-SGO1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-SGO1 Polyclonal Antibody
中文名称： 乳腺癌NY BR 85抗原抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： SGO1
别名： hSgo 1;hSgo1;NY BR 85;Serologically defined breast cancer antigen NY BR 85;Serologically defined breast cancer antigen NY-BR-85;SGO 1;SGO;SGO L1;SGO1;SGOL 1;SGOL1;SGOL1_HUMAN;Shugoshin 1AB protein;Shugoshin 1CD protein;Shugoshin 1EFprotein;Shugoshin 1GH protein;Shugoshin 1KL protein;Shugoshin like 1 (S. pombe);Shugoshin like 1;Shugoshin-like 1;
背景说明： Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
Swiss Prot： Q5FBB7
Gene ID： 151648
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of human SGO1
Public Immunogen Range： 385-435/561aa
理论分子量： 25/29/31/34/35/60/64kDa

其它标识

纯化方法： Octanoic acid-ammonium sulfate precipitation
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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