400-900-4166

Anti-MAP2K4 Polyclonal Antibody,BR

Anti-MAP2K4 Polyclonal Antibody

(订货以英文名为准)
产品编号:AC61458 品牌:Acmec

猜你喜欢

溴化锂, 99.5% metals basis

CAS No:7550-35-8

硼烷二甲硫醚, 2.0 M solution in THF, SafeSeal

CAS No:13292-87-0

聚乙二醇300, average Mn 300

CAS No:25322-68-3

组胺, 分析对照品,HPLC≥98%

CAS No:51-45-6

聚丙烯酸钠, NP-700型号

CAS No:9003-04-7

a-葡萄糖苷酶, ≥40units/mg protein 酵母

CAS No:9001-42-7

中文名称:
Anti-MAP2K4 Polyclonal Antibody
英文名称:
Anti-MAP2K4 Polyclonal Antibody
保存条件:
-20℃

产品属性 Product Attributes

基本信息

英文名称: Anti-MAP2K4 Polyclonal Antibody
中文名称: 丝裂原活化蛋白激酶激酶4抗体
规格: 100ul ; 50ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Mouse
应用: WB
稀释比例: WB 1:1000-3000.

抗体信息

靶标: MAP2K4
别名: JNKK1;MEK4;MKK4;PRKMK4;SEK1;SERK1;SKK1
背景说明: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Swiss Prot: P45985
Gene ID: 6416
亚细胞定位: Nucleus Cytoplasm
免疫原: A synthetic peptide of human MAP2K4
Public Immunogen Range: 295-345/399aa
理论分子量: 46/44kDa

其它标识

纯化方法: Affinity purification
储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
危化品级别:
关于的化合物详细属性等信息,点击“
技术资料
DATA SHEET
历史浏览记录
CAS No:20651-66-5
CAS No:531-59-9
​Copyright ◎ 2018 ACMEC-E.COM-版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任
上海吉至生化科技有限公司
沪公网安备31012002005909号   沪ICP备18007380号-1
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。
危险品化学品经营许可证    营业执照(三证合一)