- 首页
- Anti-MAP2K4 Polyclonal Antibody,BR
Anti-MAP2K4 Polyclonal Antibody,BR
Anti-MAP2K4 Polyclonal Antibody
(订货以英文名为准)猜你喜欢
CAS No:652-03-9
CAS No:13292-87-0
CAS No:25322-68-3
CAS No:50585-87-0
CAS No:6972-86-7
CAS No:55321-99-8
CAS No:70264-94-7
产品属性 Product Attributes
基本信息
英文名称: Anti-MAP2K4 Polyclonal Antibody中文名称: 丝裂原活化蛋白激酶激酶4抗体
规格: 100ul ; 50ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Mouse
应用: WB
稀释比例: WB 1:1000-3000.
抗体信息
靶标: MAP2K4别名: JNKK1;MEK4;MKK4;PRKMK4;SEK1;SERK1;SKK1
背景说明: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
Swiss Prot: P45985
Gene ID: 6416
亚细胞定位: Nucleus Cytoplasm
免疫原: A synthetic peptide of human MAP2K4
Public Immunogen Range: 295-345/399aa
理论分子量: 46/44kDa
其它标识
纯化方法: Affinity purification储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.
产品介绍 Product Introduction
使用前请离心。如有问题请及时联系我们。Quick spin before use. If you have any questions, please contact us.
注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。