Anti-NTRK1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-NTRK1 Polyclonal Antibody
中文名称： 酪氨酸激酶A抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Rat ; Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： NTRK1
别名： NTRK1,MTC,TRK,TRK1,TRKA,Trk-A,p140-TrkA,neurotrophic receptor tyrosine kinase 1
背景说明： Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.
Swiss Prot： P04629
Gene ID： 4914
亚细胞定位： Cytoplasm Cell membrane
免疫原： A synthetic peptide of human NTRK1
Public Immunogen Range： 670-720/796aa
理论分子量： 77/84/87kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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