Anti-WAC Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-WAC Polyclonal Antibody
中文名称： WW结构域包含带螺旋线圈的适配蛋白抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： WAC
别名： 1110067P07Rik, BA48B24, BA48B24.1, BM 016, FLJ31290, KIAA1844, MGC10753,
背景说明： Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) ref. Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription ref. Regulates the cell-cycle checkpoint activation in response to DNA damage ref. Positive regulator of amino acid starvation-induced autophagy ref. Also acts as a negative regulator of basal autophagy ref. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation ref. May negatively regulate the ubiquitin proteasome pathway ref.
Swiss Prot： Q9BTA9
Gene ID： 51322
亚细胞定位： Nucleus Cytoplasm
免疫原： Recombinant protein of human WAC
Public Immunogen Range： 1-210aa
理论分子量： 71/65/59/48kDa

其它标识

纯化方法： Octanoic acid-ammonium sulfate precipitation
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。