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Anti-CHMP2A Polyclonal Antibody,BR
Anti-CHMP2A Polyclonal Antibody
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产品属性 Product Attributes
基本信息
英文名称: Anti-CHMP2A Polyclonal Antibody中文名称: 染色质修饰蛋白2A抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Mouse
应用: IHC
稀释比例: IHC 1:100-300.
抗体信息
靶标: CHMP2A别名: BC 2;BC2;Charged multivesicular body protein 2a;CHM2A_HUMAN;CHMP2;CHMP2a;Chromatin modifying protein 2a;Chromatin-modifying protein 2a;hVps2 1;hVps2-1;putative breast adenocarcinoma marker;Putative breast adenocarcinoma marker BC-2;Putative breast adenocarcinoma marker BC2;Vacuolar protein sorting associated protein 2 1;Vacuolar protein sorting-associated protein 2-1;Vps2 1;VPS2;Vps2-1;VPS2A;
背景说明: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Swiss Prot: O43633
Gene ID: 27243
亚细胞定位: Cytoplasm
免疫原: Recombinant protein of human CHMP2A
Public Immunogen Range: 1-222aa
理论分子量: 25kDa
其它标识
纯化方法: Octanoic acid-ammonium sulfate precipitation储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.
产品介绍 Product Introduction
使用前请离心。如有问题请及时联系我们。Quick spin before use. If you have any questions, please contact us.
注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。