Anti-PARP3 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PARP3 Polyclonal Antibody
中文名称： 聚ADP核糖聚合酶家族成员3抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human
应用： IHC
稀释比例： IHC 1:100-300.

抗体信息

靶标： PARP3
别名： hPARP3, IRT1, NAD(+) ADP ribosyltransferase 3, pADPRT 3, Poly[ADP ribose] synthetase 3, ADP ribosyltransferase (NAD+, poly (ADP ribose), ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, hPARP 3, hPARP-3, IRT 1, IRT1, NAD(+) ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, Poly (ADP ribose) polymerase family, member 3, Poly (ADP ribose) synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP-ribose] synthase 3
背景说明： Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin.
Swiss Prot： Q9Y6F1
Gene ID： 10039
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human PARP3
Public Immunogen Range： 1-51/533aa
理论分子量： 60/61kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。