Anti-TDP2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-TDP2 Polyclonal Antibody
中文名称： TRAF和TNF受体相关蛋白抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse
应用： WB ; IHC
稀释比例： WB 1:2000-5000. IHC 1:25-100.

抗体信息

靶标： TDP2
别名： 5 Tyr DNA phosphodiesterase,AD022,EAP2,EAPII,ETS1 associated protein 2,ETS1 associated protein II,TDP2,TTRAP,Tyr DNA phosphodiesterase 2
背景说明： DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Swiss Prot： O95551
Gene ID： 51567
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human TDP2
Public Immunogen Range： 1-377aa
理论分子量： 44/41/32kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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