Anti-APEX2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-APEX2 Polyclonal Antibody
中文名称： APEX核酸酶2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB
稀释比例： WB 1:1000-3000.

抗体信息

靶标： APEX2
别名： AP endonuclease 2, AP endonuclease XTH2, APE 2, APE2, APEX 2, APEX L2, APEX nuclease (apurinic/apyrimidinic endonuclease) 2, APEX Nuclease 2, APEX nuclease like 2, APEXL 2, APEXL2, Apurinic apyrimidinic endonuclease 2, Apurinic/apyrimidinic endonuclease 2, Apurinic/apyrimidinic endonuclease like 2, C430040P13Rik, DNA (apurinic or apyrimidinic site) lyase 2, XTH 2, XTH2, APEX2_HUMAN
背景说明： Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
Swiss Prot： Q9UBZ4
Gene ID： 27301
亚细胞定位： Nucleus Cytoplasm
免疫原： Recombinant protein of human APEX2
Public Immunogen Range： 172-521aa
理论分子量： 57kDa

其它标识

纯化方法： Octanoic acid-ammonium sulfate precipitation
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。