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- Anti-SLC8B1 Polyclonal Antibody,BR
Anti-SLC8B1 Polyclonal Antibody,BR
Anti-SLC8B1 Polyclonal Antibody
(订货以英文名为准)猜你喜欢
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产品属性 Product Attributes
基本信息
英文名称: Anti-SLC8B1 Polyclonal Antibody中文名称: 溶质载体家族24成员6抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human
应用: IHC
稀释比例: IHC 1:50-200.
抗体信息
靶标: SLC8B1别名: FLJ22233, Na(+)/K(+)/Ca(2+) exchange protein 6, Na(+)/K(+)/Ca(2+)-exchange protein 6, NCKX6, NCKX6_HUMAN, NCLX, Slc24a6, Sodium/potassium/calcium exchanger, Sodium/potassium/calcium exchanger 6, Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6, Solute carrier family 24 member 6
背景说明: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).
Swiss Prot: Q6J4K2
Gene ID: 80024
亚细胞定位: Cytoplasm
免疫原: A synthetic peptide of human SLC8B1
Public Immunogen Range: 25-75/584aa
理论分子量: 58/64kDa
其它标识
纯化方法: Affinity purification储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.
产品介绍 Product Introduction
使用前请离心。如有问题请及时联系我们。Quick spin before use. If you have any questions, please contact us.
注意事项 Considerations
1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。2.为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。