Anti-FZD5/8 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-FZD5/8 Polyclonal Antibody
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Rat ; Human预测
交叉反应：： Zebrafish
应用： IHC ; WB
稀释比例： WB 1:1000-3000. IHC 1:100-300.

抗体信息

靶标： FZD5/8
别名： C2orf31, DKFZP434E2135, Frizzled homolog 5, Frizzled-5, Frizzled5, Fz 5, Fz-5, Fz5, FZD 5, hFz5, FZD5, FZD5_HUMAN, FzE 5, FzE5, HFZ 5, HFZ5, MGC129692, Seven transmembrane receptor frizzled 5, Uncharacterized protein C2orf31, Wnt receptor, FZD8, Frizzled 8, FZ 8
背景说明： Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Swiss Prot： Q13467/Q9H461
Gene ID： 7855/8325
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of Human FZD5/8
Public Immunogen Range： 30-80/585aa
理论分子量： 65/73kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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