Anti-CAMK2D Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-CAMK2D Polyclonal Antibody
中文名称： 钙/钙调素依赖性蛋白激酶Ⅱδ抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC 1:100-300.

抗体信息

靶标： CAMK2D
别名： CaMK II delta, Calcium / calmodulin dependent protein kinase 2 delta, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin-dependent protein kinase type II subunit delta, CAM kinase 2 delta, CAM kinase II delta, CaM kinase II subunit delta, CAMK 2d, CaMK-II subunit delta, CAMK2D, CAMKD, CAMKI, KCC2D_HUMAN, RATCAMKI
背景说明： Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
Swiss Prot： Q13557
Gene ID： 817
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of Human CAMK2D
Public Immunogen Range： 131-479aa
理论分子量： 54/56/58/59kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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