Anti-PTGS2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PTGS2 Polyclonal Antibody
中文名称： 环氧合酶2/前列腺素内过氧化物合成酶2抗体
规格： 50ul ; 100ul ; 20ul
宿主： Rabbit
亚型： IgG
交叉反应： Human ; Mouse预测
交叉反应： Rabbit(85.7%);Horse(85.7%)
应用： IF-C ; ELISA
稀释比例： IF-C 1:50-200. ELISA 1:1000-10000.

抗体信息

靶标： PTGS2
别名： COX-2;PHS II;PGH synthase 2;PGHS-2;COX2
背景说明： Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids.
Swiss Prot： P35354
Gene ID： 5743
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human PTGS2 种属同源性预测Public Immunogen Range 180-230/604aa
理论分子量： 69kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.
运输条件： 冷冻运输 种属同源性预测

产品介绍 Product Introduction

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注意事项 Considerations

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