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Anti-KCND2 Polyclonal Antibody,BR

Anti-KCND2 Polyclonal Antibody

(订货以英文名为准)
产品编号:AC62147 品牌:Acmec
中文名称:
Anti-KCND2 Polyclonal Antibody
英文名称:
Anti-KCND2 Polyclonal Antibody
保存条件:
-20℃

产品属性 Product Attributes

基本信息

英文名称: Anti-KCND2 Polyclonal Antibody
中文名称: 钾电压门控通道Shal相关亚家族成员2抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Rat ; Mouse
应用: WB
稀释比例: WB 1:1000-3000.

抗体信息

靶标: KCND2
别名: Potassium voltage-gated channel subfamily D member 2, KCD2, KCND 2, KCND2, KCND2_HUMAN, KIAA1044, Potassium voltage gated channel Shal related subfamily member 2, RK 5, RK5, Voltage gated potassium channel Kv4.2, Voltage gated potassium channel subunit Kv4.2, Voltage sensitive potassium channel, voltage-gated potassium channel Kv4.2, Voltage-gated potassium channel subunit Kv4.2, voltage-sensitive potassium channel
背景说明: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3; channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity; it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation. Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity).
Swiss Prot: Q9NZV8
Gene ID: 3751
亚细胞定位: Cell membrane
免疫原: A synthetic peptide of human KCND2
Public Immunogen Range: 510-560/630aa
理论分子量: 71kDa

其它标识

纯化方法: Affinity purification
储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
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