Anti-LIMK1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-LIMK1 Polyclonal Antibody
中文名称： 单丝氨酸蛋白激酶1抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： LIMK1
别名： EC 2.7.11.1,LIM domain kinase 1,LIM motif-containing protein kinase,LIMK,LIMK-1
背景说明： Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development.
Swiss Prot： P53667
Gene ID： 3984
亚细胞定位： Cytoplasm Nucleus
免疫原： A synthetic peptide of human LIMK1
Public Immunogen Range： 465-515/647aa
理论分子量： 73/71/69/33kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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