Anti-LIMK2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-LIMK2 Polyclonal Antibody
中文名称： LIM结构域激酶2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： LIMK2
别名： LIMK2,LIM domain kinase 2,LIMK-2,EC 2.7.11.1
背景说明： There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Swiss Prot： P53671
Gene ID： 3985
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human LIMK2
Public Immunogen Range： 450-500/638aa
理论分子量： 70/72/78kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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