Anti-GAPDH Polyclonal Antibody,BR

宿主:Rabbit
别名:G3PD;GAPD;HEL-S-162eP
靶标:GAPDH
交叉反应:Human Mouse Rat
应用:WB IHC
稀释比例:WB 1:8000-12000. IHC 1:50-200.
蛋白分子量:32/36kDa
Gene ID:2597
保存:Store at -20°C. Avoid freeze / thaw cycles.
储存液:Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法:Affinity purification
亚型:IgG
免疫原:Recombinant protein of human GAPDH
亚细胞定位:Cytoplasm Nucleus
Swiss Prot:P04406
背景资料:Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.
Public Immunogen Range:1-336aa
克隆类型:Polyclonal Antibody
规格:50ul, 100ul, 注意：
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