Anti-DTNBP1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-DTNBP1 Polyclonal Antibody
中文名称： 肌萎缩dystrobrevin结合蛋白1抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC 1:50-200.

抗体信息

靶标： DTNBP1
别名： Dysbindin-1, 5430437B18Rik, AW048963, dysbindin, sdy, DTNBP1, Dystrobrevin binding protein 1, Hermansky Pudlak syndrome 7 protein, HPS7, DTBP1_HUMAN, Dystrobrevin-binding protein-1, Hermansky-Pudlak syndrome 7 protein, HPS7 protein
背景说明： Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
Swiss Prot： Q96EV8
Gene ID： 84062
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human DTNBP1
Public Immunogen Range： 1-350aa
理论分子量： 30/35/39kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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