Anti-ATP2A2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-ATP2A2 Polyclonal Antibody
中文名称： 钙离子转运ATP酶A2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： WB ; IHC
稀释比例： WB 1:1000-3000. IHC 1:50-200.

抗体信息

靶标： ATP2A2
别名： ATP dependent calcium pumpsc, ATP2A2, ATP2B, ATPase Ca++ transporting cardiac muscle slow twitch 2, Ca++ transporting cardiac muscle slow twitch 2, Calcium pump 2, Calcium-transporting ATPase sarcoplasmic reticulum type slow twitch skeletal muscle isoform, DAR, Darier disease, DD, Endoplasmic reticulum class 1/2 Ca(2+) ATPase, Sarcoplasmic or endoplasmic reticulum calcium ATP, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA 2, SERCA2, SR Ca(2+)-ATPase 2, AT2A2_HUMAN
背景说明： This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle (PubMed:16402920). Acts as a regulator of TNFSF11-mediated Ca2+ signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (By similarity).
Swiss Prot： P16615
Gene ID： 488
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human ATP2A2
Public Immunogen Range： 483-700aa
理论分子量： 110/112/115kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。