Anti-NFE2L2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-NFE2L2 Polyclonal Antibody
中文名称： 核因子E2相关因子2抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC ; IF
稀释比例： IHC 1:100-300. IF 1:50-200.

抗体信息

靶标： NFE2L2
别名： HEBP1,NF E2 related factor 2,NFE2 related factor 2,NFE2L2,NRF2
背景说明： Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092).
Swiss Prot： Q16236
Gene ID： 4780
亚细胞定位： Cytoplasm Nucleus
免疫原： Recombinant protein of human NFE2L2
Public Immunogen Range： 1-350aa
理论分子量： 65/66/68kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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