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Anti-HMCES Polyclonal Antibody,BR

Anti-HMCES Polyclonal Antibody

(订货以英文名为准)
产品编号:AC62870 品牌:Acmec

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中文名称:
Anti-HMCES Polyclonal Antibody
英文名称:
Anti-HMCES Polyclonal Antibody
保存条件:
-20℃

产品属性 Product Attributes

基本信息

英文名称: Anti-HMCES Polyclonal Antibody
中文名称: 3号染色体开放阅读框37抗体
规格: 50ul ; 100ul
宿主: Rabbit
克隆类型: Polyclonal Antibody
亚型: IgG
交叉反应:: Human ; Rat ; Mouse
应用: IHC
稀释比例: IHC 1:50-200.

抗体信息

靶标: HMCES
别名: Abasic site processing protein HMCES;Peptidase HMCES;SRAP domain-containing protein 1;C3orf37;DC12;SRAPD1;
背景说明: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity).
Swiss Prot: Q96FZ2
Gene ID: 56941
亚细胞定位: Nucleus Cytoplasm
免疫原: Recombinant protein of human HMCES
Public Immunogen Range: 1-354aa
理论分子量: 41kDa

其它标识

纯化方法: Octanoic acid-ammonium sulfate precipitation
储存液: PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3.
储存条件: Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.

注意事项 Considerations

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3.实验结果可由多种因素影响,相关处理只限于产品本身,不涉及其他赔偿。
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