Anti-FBXO9 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-FBXO9 Polyclonal Antibody
中文名称： F-box蛋白9抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Rat ; Mouse
应用： IHC
稀释比例： IHC 1:100-300.

抗体信息

靶标： FBXO9
别名： Cross-immune reaction antigen 1, dJ341E18.2, DKFZp434C0118, F-box only protein 9, Fbp24, FBX9, FBX9_HUMAN, Fbxo9, KIAA0936, NY REN 57,
背景说明： Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Swiss Prot： Q9UK97
Gene ID： 26268
亚细胞定位： Cytoplasm
免疫原： Recombinant protein of human FBXO9
Public Immunogen Range： 1-350aa
理论分子量： 47/51/52kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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