Anti-MBTPS2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-MBTPS2 Polyclonal Antibody
中文名称： S2P内肽酶抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human预测
交叉反应：： Cow;Chimpanzee;Hamster
应用： IHC
稀释比例： IHC 1:100-300.

抗体信息

靶标： MBTPS2
别名： BRESEK, Endopeptidase S2P, IFAP, KFSDX, MBTP2_HUMAN, MBTPS2, Membrane bound transcription factor site 2 protease, membrane-bound transcription factor peptidase, site 2, membrane-bound transcription factor protease, site 2, Membrane-bound transcription factor site-2 protease, S2P, S2P endopeptidase, Site 2 protease, SREBPs intramembrane protease, Sterol regulatory element-binding proteins intramembrane protease
背景说明： Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209, PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894).
Swiss Prot： O43462
Gene ID： 51360
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human MBTPS2
Public Immunogen Range： 5-55/519aa
理论分子量： 57kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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