Anti-APH1A Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-APH1A Polyclonal Antibody
中文名称： 早老素γ分泌酶抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Human ; Mouse
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： APH1A
别名： Anterior Pharynx Defective 1, Anterior pharynx defective 1 homolog A, APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, Aph1a, APH1A_HUMAN, CGI 78, CGI78, Gamma secretase subunit APH 1A, Gamma Secretase Subunit APH1a, Gamma-secretase subunit APH-1A, Likely ortholog of C. elegans anterior pharynx defective 1A, Presenilin Stabilization Factor, Presenilin-stabilization factor, PSF, UNQ579/PRO1141
背景说明： This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
Swiss Prot： Q96BI3
Gene ID： 51107
亚细胞定位： Cytoplasm
免疫原： A synthetic peptide of human APH1A
Public Immunogen Range： 215-265/265aa
理论分子量： 21/27/29kDa

其它标识

纯化方法： Octanoic acid-ammonium sulfate precipitation
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

使用前请离心。如有问题请及时联系我们。
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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。