Anti-phospho-MLKL (S358) Monoclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-phospho-MLKL (S358) Monoclonal Antibody
中文名称： 混合系列蛋白激酶样结构域抗体
规格： 50ul ; 100ul
宿主： Mouse
克隆类型： Monoclonal Antibody
亚型： IgG1克隆号 6B4
交叉反应：： Human
应用： IHC
稀释比例： IHC 1:50-200.

抗体信息

靶标： phospho-MLKL (S358)
别名： 9130019I15Rik, FLJ34389, hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain-like protein, MLKL_HUMAN
背景说明： This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Swiss Prot： Q8NB16
Gene ID： 197259
亚细胞定位： Cell membrane Cytoplasm
免疫原： Synthetic Peptide
理论分子量： 30/54kDa

其它标识

纯化方法： Octanoic acid-ammonium sulfate precipitation
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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