Recombinant Human UBE2G2/Ubiquitin-conjugating enzyme E2 G2,BR

产品属性 Product Attributes

基本信息

别名： Ubiquitin-Conjugating Enzyme E2 G2;Ubiquitin Carrier Protein G2;Ubiquitin-Protein Ligase G2;UBE2G2
中文名称: Recombinant Human UBE2G2/Ubiquitin-conjugating enzyme E2 G2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 2mM DTT, 10% Glycerol, pH 7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation，which belong to the ubiquitin-conjugating enzyme family.It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively.The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins.The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate.The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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