Recombinant Human B2M/β2-Microglobulin/Beta-2-microglobulin,BR

产品属性 Product Attributes

基本信息

别名： Beta-2-Microglobulin;B2M
中文名称: Recombinant Human B2M/β2-Microglobulin/Beta-2-microglobulin
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS，PH7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family.B2M component of major histocompatibility complex (MHC) class I molecules，involved in the presentation of peptide antigens to the immune system.Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells.Serum B2M concentration is increased in renal diseases，various malignant diseases and some inflammatory and autoimmune disorders.B2M may adopt the fibrillar configuration of amyloid in certain pathologic states.The capacity to assemble into amyloid fibrils is concentration dependent.B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis.B2M might be involved in the OA (osteoarthritis) pathogenesis.Defects in B2M are the cause of hypercatabolic hypoproteinemia.Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin，probably due to rapid degradation.B2M could be a potential therapeutic target in ovarian cancer.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。