Recombinant Mouse IgG2A Fc,BR

产品属性 Product Attributes

基本信息

别名： Ig gamma-2 chain C region;IgG2A Fc
中文名称: Recombinant Mouse IgG2A Fc
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution ofPBS, PH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta，Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells，and constitutes 75% of serum immunoglobulins in humans.IgG antibodies protect the body against the pathogens by agglutination and immobilization，complement activation，toxin neutralization，as well as the antibody-dependent cell-mediated cytotoxicity (ADCC).IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds，that is the two identical halves form the Y-like shape.IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment (crystallizable fragment).IgG1 is most abundant in serum among the four IgG subclasses (IgG1，2，3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity.Fc fragment is demonstrated to mediate phagocytosis，trigger inflammation，and target Ig to particular tissues.Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs，and has numerous applications in biotechnology as a reagent for affinity purification.Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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