Recombinant Human Osteoprotegerin/TNFRSF11B/OPG,BR

产品属性 Product Attributes

基本信息

别名： Tumor Necrosis Factor Receptor Superfamily Member 11B;Osteoclastogenesis Inhibitory Factor;Osteoprotegerin;TNFRSF11B;OCIF;OPG
中文名称: Recombinant Human Osteoprotegerin/TNFRSF11B/OPG
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： TNFRSF11B is a secreted protein，containing 2 death domains and 4 TNFR-Cys repeats.TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL).By binding RANKL，TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes，and a key regulator of inflammation，innate immunity，and cell survival and differentiation.TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2.TNFRSF11B can reduce the production of osteoclasts by inhibiting the differentiation of osteoclast precursors (osteoclasts are related to monocytes/macrophages and are derived from granulocyte/macrophage-forming colony units (CFU-GM)) into osteoclasts and also regulates the resorption of osteoclasts in vitroand in vivo.TNFRSF11B binding to RANKL on osteoblast/stromal cells，blocks the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors.This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

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