Recombinant Human SMAD4/SMAD family member 4,BR

产品属性 Product Attributes

基本信息

别名： Mothers Against Decapentaplegic Homolog 4;MAD Homolog 4;Mothers Against DPP Homolog 4;Deletion Target in Pancreatic Carcinoma 4;SMAD Family Member 4;SMAD 4;Smad4;hSMAD4;SMAD4;DPC4;MADH4
中文名称: Recombinant Human SMAD4/SMAD family member 4
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM TrisHCl, pH8.0.
纯度: Greater than85% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family.SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain.It is the component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.SMAD4 promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription.SMAD4 may act as a tumor suppressor.It positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.Mutations or deletions in SMAD4 have been shown to result in pancreatic cancer，juvenile polyposis syndrome，and hereditary hemorrhagic telangiectasia syndrome.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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