Recombinant Human Myeloperoxidase/MPO,BR

产品属性 Product Attributes

基本信息

别名： Myeloperoxidase;MPO
中文名称: Recombinant Human Myeloperoxidase/MPO
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Myeloperoxidase (MPO) is a heme-containingenzyme belonging to the XPO subfamily of peroxidases.It is an abundant neutrophil and monocyte glycoprotein thatcatalyzes the hydrogen peroxide-dependentconversion of chloride，bromide，and iodide to multiple reactive species.Post-translationalprocessing of MPO involvesthe insertion of a heme moiety and the proteolytic removal of both a propeptide and a 6 aa internal peptide.This results in a disulfide-linkeddimer composed of a60 kDa heavy and 12 kDa light chain that associate into a 150 kDa enzymatically active tetramer.The tetramer contains two heme groups and one disulfide bondbetween the heavy chains.Alternate splicing generates two additional isoforms of MPO，one with a 32 aa insertion in the light chain，and another with a deletion ofthe signal sequence and part of the propeptide.Human and mouse MPO share 87% aa sequence identity.MPO activity results in protein nitrosylation and theformation of 3-chlorotyrosineand dityrosine crosslinks.MPO is also associated with a variety of other diseases，and inhibits vasodilation in inflammation by depleting the levelsof NO.Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells.MPO is stored in neutrophil azurophilicgranules.Upon cellular activation，it is deposited into pathogen-containingphagosomes.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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