Recombinant Mouse PD-L2/B7-DC/CD273/Programmed cell death ligand 2,BR

产品属性 Product Attributes

基本信息

别名： Programmed cell death 1 ligand 2;Pdcd1lg2;PD-1 ligand 2;PD-L2;PDCD1 ligand 2;B7-DC;CD273;
中文名称: Recombinant Mouse PD-L2/B7-DC/CD273/Programmed cell death ligand 2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Programmed cell death 1 ligand 2 (PD-L2)，also known as butyrophilin B7-DC or PDCD1 ligand 2，belongs to the member of B7 family which can regulate the activation and tolerance ofT cells.PD-L2 is one ligand for Programmed cell death 1(PD-1)，and the other is PD-L1.These two ligands shares 34% aa sequence identity.Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide，a 201 aa extracellular region，a 21 aa transmembrane domain and a 32 aa cytoplasmic region.The mouse PD-L2 gene is highly expressed in heart，placenta，pancreas，lung and liver while expressed weakly in spleen，lymph nodes and thymus.Besides，the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment，and up-regulated by IFNG/IFN-gamma stimulation in monocytes.PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production.Recent studies demonstrate that the expression of PD-L2 on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells，at both the induction and effector phase of antitumor immunity.Moreover，PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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