Recombinant Human Ephrin A Receptor 2/EphA2,BR

产品属性 Product Attributes

基本信息

别名： Ephrin type-A receptor 2;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK;EPHA2
中文名称: Recombinant Human Ephrin A Receptor 2/EphA2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,5% Trehalose,ph7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： EphA2 is a member of the Eph receptor tyrosine kinase family which binds Ephrins A1，2，3，4，and 5.Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells，leading to contact-dependent bidirectional signaling into neighboring cells.The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.EphA2 becomes autophosphorylated following ligand binding and then interacts with SH2 domain-containing PI3-kinase to activate MAPK pathways.Reverse signaling is also propagated through the Ephrin ligand.Transcription of EphA2 is dependent on the expression of E-Cadherin，and can be induced by p53 family transcription factors.EphA2 is upregulated in breast，prostate，and colon cancer vascular endothelium.Its ligand，EphrinA1，is expressed by the local tumor cells.In some cases，EphA2 and EphrinA1 are expressed on the same blood vessels.EphA2 signaling cooperates with VEGF receptor signaling in promoting endothelial cell migration.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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