Recombinant Human CD106/VCAM-1/L1CAM,BR

产品属性 Product Attributes

基本信息

别名： Vascular Cell Adhesion Protein 1;V-CAM 1;VCAM-1;INCAM-100;CD106;VCAM1;L1CAM
中文名称: Recombinant Human CD106/VCAM-1/L1CAM
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 2mM CaCl2, 2mM MgCl2, 5% Threhalose, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： VCAM-1 is a single-pass type I membrane protein，contains 7 Ig-like C2-type domains.It is an endothelial ligand for very late antigen-4 (VLA-4) and α4-7 integrin expressed on leukocytes，and thus mediates leukocyte-endothelial cell adhesion and signal transduction.VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease，atherosclerosis，allograft rejection，infection，and asthmatic responses.During these responses，VCAM-1 forms a scaffold for leukocyte migration.VCAM-1 also activates signals within endothelial cells resulting in the opening of an endothelial cell gate through which leukocytes migrate.VCAM-1 has been identified as a potential anti-inflammatory therapeutic target，the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis.In addition，VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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