Recombinant Human Osteopontin/OPN/SPP-1/SPP1,BR

产品属性 Product Attributes

基本信息

别名： Osteopontin;Bone Sialoprotein 1;Nephropontin;Secreted Phosphoprotein 1;SPP-1;Urinary Stone Protein;Uropontin;SPP1;BNSP;OPN
中文名称: Recombinant Human Osteopontin/OPN/SPP-1/SPP1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Secreted Phosphoprotein 1 (SPP1) is a secreted multifunctional glycoprotein.Its putative functions include roles in bone metabolism，immune regulation，wound healing，cell survival，and tumor progression.Based on gene structure and chromosomal location，SPP1 is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family that also includes bone sialoprotein (BSP)，dentin matrix protein 1 (DMP1)，dentin sialophosphoprotein (DSPP)，enamelin (ENAM)，and matrix extracellular phosphoglycoprotein (MEPE).SPP1 is expressed in bone，although it is also expressed in other tissues.SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10.It is essential in the pathway that leads to type I immunity.Osteopontin has been implicated as an important factor in bone remodeling.Specifically，research suggests it plays a role in anchoring osteoclasts to the mineral matrix of bones.The fact that SPP1 interacts with multiple cell surface receptors which are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing，bone turnover，tumorigenesis，inflammation and ischemia.Therefore，manipulation of plasma Osteopontin levels may be useful in the treatment of autoimmune diseases，cancer metastasis，osteoporosis and some forms of stress.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。